The following main changes were made: (1) The use of computed tomography (CT) scanning is allowed to assess disease involvement below the diaphragm. Involvement of lymph node regions on both sides of the diaphragm (III) which may also be accompanied by localised involvement of extralymphatic organ or site (IIIE) or by involvement of the spleen (IIIS) or both (IIISE). 1. B = with symptoms including unexplained weight loss (10% in 6 months prior to diagnosis, unexplained fever, and drenching night sweats.) We encourage applications to be submitted by email in order to avoid delay. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780323240987000769, URL: https://www.sciencedirect.com/science/article/pii/B9781437716375000742, URL: https://www.sciencedirect.com/science/article/pii/B9780123851833000267, URL: https://www.sciencedirect.com/science/article/pii/B9781416039938000428, URL: https://www.sciencedirect.com/science/article/pii/B9781416058977000615, URL: https://www.sciencedirect.com/science/article/pii/B9780323357623000846, URL: https://www.sciencedirect.com/science/article/pii/B9781437722321000164, URL: https://www.sciencedirect.com/science/article/pii/B9780721600819500364, URL: https://www.sciencedirect.com/science/article/pii/B9780323072557000386, URL: https://www.sciencedirect.com/science/article/pii/B9780323240987000976, Clinical Radiation Oncology (Fourth Edition), Clinical Radiation Oncology (Third Edition), Alex Hakim MD, ... Nader Kamangar MD, FACP, FCCP, in, Medical Management of the Thoracic Surgery Patient, Richard T. Hoppe MD, FACR, FASTRO, Sandra J.Horning MD, in, Leibel and Phillips Textbook of Radiation Oncology (Third Edition), Kara M. Kelly, ... Catherine M. Bollard, in, Yulia Bronstein M.D., ... Paul M. Silverman M.D., in, Oncologic Imaging: A Multidisciplinary Approach, Hodgkin Lymphoma and Non-Hodgkin Lymphoma, Staging has both clinical and pathologic features. Involvement of a single lymph node region (I) or of a single extra-lymphatic organ or site (IE). The staging system used for Hodgkin lymphoma is the Lugano classification, which is based on the older Ann Arbor system. Because of its low diagnostic value, routine bone marrow examination might be unnecessary for staging when FDG‐PET/CT is used as a substitute. These factors were found to correlate significantly with shorter overall or relapse-free survival. As in young patients, the Ann Arbor staging system for Hodgkin's lymphoma has proved inappropriate in the elderly, and since 1993, prognosis is better described by the International Prognostic Index than the stage.25 The International Prognostic Index includes age (less than or more than 60 years); disease stage (localized or disseminated); performance status (good, 0 to 1; poor, >1); lactate dehydrogenase (LDH) levels (normal or above normal); and number of extranodal disease sites (0 to 1 or >1) to classify patients into four risk categories, ranging from low-risk to high-risk categories. We encourage applications to be submitted by email in order to avoid delay. What people with cancer should know: https://www.cancer.gov/coronavirus, Guidance for cancer researchers: https://www.cancer.gov/coronavirus-researchers, Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus. The definition of these stages can be found in the AJCC Cancer Staging Manual (7th edition) or Union for International Cancer Control (UICC) staging manual. The Ann Arbor staging classification (Table 76-3), developed in 1971, is a four-stage system formulated to provide prognostic information and to guide therapeutic decisions. In 1988, revisions to the Ann Arbor staging system were made based on a meeting in Coltswolds, England (Table 76-4).51 Main changes include the following: (1) Allowed the use of CT scanning to assess disease involvement below the diaphragm. To obtain this permit, complete the Zoning Application for Change of Use/Temporary Outdoor Sales (PDF). The Ann Arbor staging system is widely used for anatomic staging of lymphoma, both Hodgkin and non-Hodgkin lymphomas. (2) For stage II disease, the number of anatomic nodal sites were indicated by a subscript (e.g., stage II3). Using the Dynamic Map, you may search by Address or Zoning Section. Reason: excludes skin of eyelid and eye because AJCC 7th ed does not include information on Ann Arbor for lymphoma ocular adnexa. Some authors’ inclusion of these patients in stage IV has led to a great deal of confusion in the literature. * Chapter 80 *Pediatric Hodgkin and Non-Hodgkin Lymphomas*, in the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. A = without symptoms. Ann Arbor staging system is the most commonly used for Non-Hodgkin’s Lymphoma Staging. The *Lugano classification* includes an E suffix for lymphoma with either localized extralymphatic presentations (Stage IE) or by contiguous spread from nodal disease (Stage IIE). Significant systemic (B) symptoms include fevers, night sweats, and weight loss. 9 = Unknown, Based on EOD 10 - extent (1988-2003); CS extension (2004-2015); EOD 4 - extent (1983-1987).