Ndanusa BU, Mustapha A, Abdu-Aguye I. The effect of single does of rifampicin on the pharmacokinetics of oral nifedipine. J Pharm Biomed Anal 1997; 15:1571. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, … It should be taken with other medicines to prevent the spread of infection. Rifampin is an anti-tuberculosis agent with a wide array of side effects. If you had liver problems while taking some other drug in the past. Isoniazid and rifampin may cause temporary discoloration of your teeth, sweat, urine, saliva, and tears (a yellow, orange, red, or brown color). Rifampin greatly reduces plasma simvastatin and simvastatin … This side effect is usually not harmful. Some side effects may occur that usually do not need medical attention. Liver function and serum concentrations of rifampicin, a highly cholephilic antibiotic, have been studied after ingestion of a single dose of 600 mg of rifampicin in 12 patients, six of them having a normal liver and six a cirrhotic, and during treatment with 600 mg of rifampicin per day for 17 days in eight patients, four of them having a normal liver and four a cirrhotic. These side effects may go away during treatment as your body adjusts to the medicine. Find information about common, infrequent and rare side effects of Rifampin Oral. However, soft contact lenses may be permanently stained if you wear them while taking isoniazid and rifampin. This medicine may cause reddish colouration of the urine, sweat, sputum and tears. Rifampicin is an antitubercular medicine which helps to treat tuberculosis and meningococcal meningitis. Its toxicity is predominantly hepatic and immunoallergic in character. It is not dangerous, but can be disturbing to the patient due to its cosmetic effects 2. Rifampin will cause urine, saliva, sputum, sweat, teeth, and tears to turn a reddish-orange to reddish-brown color. Standard cleaning solutions may not take out all … Kyrklund C, Backman JT, Kivistö KT, et al. This effect may also cause soft contact lenses to become permanently discolored. While hepatic toxicity is dose related and has been observed mainly in patients with underlying liver disease, the immunoallergic effects are usually associated with intermittent or prolonged therapy. Rifampin. Abstract. Buy Rifampicin Online. One prominent effect is a reddish-orange discoloration of body fluids, such as saliva, tears, urine and perspiration. If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this drug, like certain drugs that are used for HIV, infections, or depression. Rifampin has proved to be a valuable antibiotic with relatively few major adverse effects. If you have had very bad side effects while taking isoniazid in the past, like liver problems, drug fever, chills, or arthritis. This is to be expected while you are using this medicine.