The most frequent benign prostate conditions that cause an elevation in PSA level are prostatitis (inflammation of the prostate) and benign prostatic hyperplasia (BPH) (enlargement of the prostate). A false-positive test result may create anxiety for a man and his family and lead to additional medical procedures, such as a prostate biopsy, that can be harmful. The PSA test may give false-positive or false-negative results. A second large trial, the European Randomized Study of Screening for Prostate Cancer (ERSPC), compared prostate cancer deaths in men randomly assigned to PSA-based screening or no screening. Most often, the needles are inserted through the wall of the rectum (transrectal biopsy). The single-parameter, structure-based IsoPSA assay demonstrates improved diagnostic accuracy for detection of any prostate cancer and high-grade prostate cancer compared to a concentration-based assay of total prostate-specific antigen: A preliminary report. | Save to del.icio.us, « Fair value making things transparent? Registered training organisation code: 122206 ABN:49 008 532 072 ACN:008 532 072. Money › Bonds › Bonds Types › Asset-Backed Securities Prepayment Models for Asset-Backed Securities. Worked for: California Credit Union, WesCorp, CalFed S&L, Crocker Bank, Carroll McEntee, Federal Home Loan Bank Board (D.C.), Western Asset Management, Security Pacific National Bank. One of the largest is the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, which NCI conducted to determine whether certain screening tests can help reduce the numbers of deaths from several common cancers. The higher the CPR, the faster the associated debtors prepay on their loans. node.dataset.value : node.getAttribute('data-value'); if (selectedValue) { for (var j = 0; j < node.options.length; j++) { if(node.options[j].value === selectedValue) { node.options[j].selected = 'selected';break;}}}}}, National Association of Securities Dealers (NASD), Do Not Sell My Personal Information (CA Residents Only). A false-positive test result occurs when a man’s PSA level is elevated but no cancer is actually present. In past posts I showed you how to calculate a Constant Prepayment Rate (CPR) with an amortization schedule. if ( permalink == url ) { That way you can create your own CPR model, rather than using one CPR for the full term or using the PSA model. If you capture prepayment data for your various loan portfolios using SMM (single monthly mortality) you can use the conversion tool shown at the right to convert the speed to PSA or CPR. The CPR represents the anticipated paydown rate, stated as a percentage and calculated as an annual rate. This seasoning is incorporated in my calculations. Of those, 80 would be treated (either immediately or after a period of. Klein EA, Chait A, Hafron JM, et al. In the prostate portion of the trial, the PSA test and DRE were evaluated for their ability to decrease a man’s chances of dying from prostate cancer. These calculations are important when evaluating assets like mortgage-backed securities or other securitized bundles of loans. However, more recent studies have shown that some men with PSA levels below 4.0 ng/mL have prostate cancer and that many men with higher levels do not have prostate cancer (1). If the PSA level is still high, the doctor may recommend that the man continue with PSA tests and DREs at regular intervals to watch for any changes over time. | Typically we like to see speeds specified as either CPR (conditional prepayment rate) or PSA (Public Securities Association). Men who report prostate symptoms often undergo PSA testing (along with a DRE) to help doctors determine the nature of the problem. Another complicating factor is that studies to establish the normal range of PSA levels have been conducted primarily in populations of white men. For example, if the pool has a WAM of 357 months, the PSA calculation will start … How are researchers trying to improve the PSA test? How to Calculate Conditional Prepayment Rates (CPR)s? If you capture prepayment data for your various loan portfolios using SMM (single monthly mortality) you can use the conversion tool shown at the right to convert the speed to PSA or CPR. The CPR rates for the 100% PSA model are charted below: A 150 PSA starts at a .3 CPR, then .6, then .9, until it gets to a 9 CPR, and stays there: A 50 PSA starts a .1 CPR and goes to a 3 CPR: When pooling 30-years mortgages that are less than 30 years remaining, the PSA calculation must shift to compensate for the months already past. U.S. Preventive Health Services Task Force. Prostate-specific antigen (PSA) is a protein made by the cells of the prostate gland. This is called prepayment risk. If a man’s PSA level rises after prostate cancer treatment, his doctor will consider a number of factors before recommending further treatment. All Worldwide Rights Reserved. Most organizations recommend that men who are considering PSA screening first discuss the risks and benefits with their doctors. CPR can be be converted to single monthly mortality (SMM) rate, and vice-versa. However, as more was learned about both the benefits and harms of prostate cancer screening, a number of organizations began to caution against routine population screening. Pinsky PF, Prorok PC, Yu K, et al. Yes! The Difference in CPR Rates Among Corporate Bonds and Treasury Bonds, Single Monthly Mortality (SMM) Definition, Public Securities Association Standard Prepayment Model (PSA) Definition, Residential Mortgage-Backed Security (RMBS) Definition.